Starting XI Füllkrug makes first Premier League start against ...
Edson Álvarez is expected to be the holding anchor with Tomáš Souček and Lucas Paquetá slightly further up the pitch. The Brazilian, of course, scored West Ham's goal in Monday's 1-1 draw at AFC Bournemouth from the penalty spot.
An attacking line-up in front of the home support sees Jarrod Bowen, one of two ever-present starters this season, and Mohammed Kudus on either side of Füllkrug.
Captain Bowen makes his 300th career league appearance, having made 182 in the Premier League and 117 in the EFL Championship, while his next league goal will be the 100th of his career.
Füllkrug marked his return from a three-month injury with a goal in the 3-1 Premier League defeat at Leicester City at the start of this month and will be aiming to add to that tally against the Seagulls.
On the bench, meanwhile, defender Jean-Clair Todibo is fit enough to be included in the squad after overcoming a knock suffered against Arsenal.
Alongside Todibo on the bench will be goalkeeper Alphonse Areola, defenders Coufal and Ollie Scarles, who made his Premier League debut at Bournemouth on Monday, midfielders Guido Rodríguez, Andy Irving and Luis Guilherme, winger Crysencio Summerville and forward Danny Ings.
West Ham United: Fabiański, Wan-Bissaka, Mavropanos, Kilman, Emerson, Álvarez, Souček, Kudus, Paquetá, Bowen ©, FüllkrugSubs: Areola (GK), Scarles, Coufal, Todibo, Irving, Rodríguez, Luis Guilherme, Summerville, Ings
Brighton & Hove Albion: Verbruggen, Veltman, van Hecke, Dunk ©, Estupiñán, Baleba, Gruda, Wieffer, Mitoma, Rutter, João PedroSubs: Steele (GK), Lamptey, Julio, Ayari, Minteh, O’Riley, Enciso, Adringa, Ferguson
Referee: Rob Jones