AFFECT-EU project underscores need for AF screening to prevent stroke

People at risk should be tested for atrial fibrillation (AF) every time they attend a health appointment, according to results of the AFFECT-EU project. Patients at high risk of the disorder, such as those with heart failure or prior stroke, should be invited for a screening test, investigators behind the project have said.

Scientific coordinator Renate Schnabel (University Hospital Hamburg-Eppendorf, Hamburg, Germany), said: “Screening for atrial fibrillation can identify undiagnosed atrial fibrillation so that the condition can be managed according to guidelines, including starting anticoagulation medication to prevent strokes. AFFECT-EU has concluded that opportunistic screening, where at-risk groups are screened when they contact the healthcare system, plus targeting patients at particular risk, may be a productive and cost-effective way to implement screening across Europe.”

The four-year, EU-funded AFFECT-EU project brought together healthcare professionals, patient representatives, payers, and industry in a consortium of 26 partners, including the European Society of Cardiology (ESC), to define a feasible AF screening strategy for healthcare systems across Europe, with the ultimate aim of preventing subsequent strokes and premature death.

The ability of atrial fibrillation screening to reduce strokes was identified by the consortium in a contemporary meta-analysis in 35,836 participants. A further study by the consortium in 11 European countries found that there were no national screening programmes, and most AF was detected in patients with symptoms. But in a survey conducted by the group in 18 European countries, GPs said screening for AF was nearly as important as screening for common cancers.

A subsequent analysis by project members demonstrated that screening result in savings of stroke-related costs regardless of the method (e.g. opportunistic or targeted). Project members then developed a budget impact analysis calculator that can be used by health regulators and payers to estimate the financial impact of implementing a screening programme over a five-year period.

Regarding who is at elevated risk of AF or stroke and should therefore be screened, studies by consortium members  identified that the following are risk factors: increasing age, obesity, high blood pressure, and high blood levels of N-terminal pro B-type natriuretic peptide (NT-proBNP), which is commonly tested to diagnose heart failure.

Project manager Daniel Engler (University Hospital Hamburg-Eppendorf, Hamburg, Germany), said: “People with atrial fibrillation are more likely to be severely disabled or die from a stroke or heart failure than those without atrial fibrillation, making prevention an imperative to reduce morbidity and maintain a high quality of life. AFFECT-EU has paved the way for well-implemented atrial fibrillation screening programmes to increase the number of new diagnoses, leading to guideline-adherent care, thereby reducing stroke risk and atrial fibrillation disease burden.”