NFL DFS, Week 16: Optimal DraftKings, FanDuel daily Fantasy football picks, stacks, lineup advice

In what has become an end-of-season tradition, Ronald Jones II has come back from Fantasy football obscurity to become relevant again. With Leonard Fournette (knee, hamstring) out for at least this week, Jones steps back into a starter's role in the Tampa Bay offense against the Carolina Panthers on Sunday. The question for daily Fantasy players considering him in the Week 16 NFL DFS player pool is whether he can be a slate-breaker given the Buccaneers' COVID-19 issues.

Carolina started the season as one of the league's toughest run defenses, but have given up 548 rushing yards over its last four games. Is Jones, who has averaged 5.62 yards per carry against the Panthers throughout his career, a plug-and-play starter in your Week 16 NFL DFS lineups and NFL DFS stacks? Before locking in your NFL DFS picks for Week 16, be sure to check out the NFL DFS advice, strategy and projections from SportsLine daily Fantasy expert Mike McClure.

McClure is a legendary professional DFS player with almost $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1 percent in more than a dozen other tournaments last season.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

Now, McClure has turned his attention to the Week 16 NFL schedule and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.

Top NFL DFS picks for Week 16

One of McClure's top NFL DFS picks for Week 16 is Jaguars running back James Robinson ($5,900 on DraftKings and $8,200 on FanDuel). Ahead of last week's loss to the Houston Texans, interim head coach and former offensive coordinator Darrell Bevell said that Robinson is "the team's starting running back and will be treated as such." He backed that up by giving Robinson 18 carries, which he turned into 75 yards and a touchdown.

Robinson has another friendly defensive matchup this week against the New York Jets, who have given up the second-most rushing yards in the league this season. As rookie quarterback Trevor Lawrence continues to struggle and the Jaguars continue to play out the rest of the season, Robinson should be given a heavy workload. Seven starters on the Jets' defense are listed as either out or questionable this week, and the unit was responsible for the seventh-most missed tackles in the NFL. The Jags hold the top spot in the 2022 NFL Draft and shouldn't be looking for explosive plays in the passing game, which means more handoffs and check-downs for Robinson.

Part of McClure's optimal NFL DFS strategy includes rostering Rams wide receiver Cooper Kupp ($8,800 on DraftKings and $9,500 on FanDuel). Kupp is coming off another dominant performance against the Seahawks, recording nine receptions for 136 yards and two touchdowns.

Kupp has now scored four touchdowns in his last three games and enters Sunday's contest against the Vikings ranked first in receptions (122), receiving yards (1,625) and touchdowns (14). He's also recorded 120 or more receiving yards in four of his last five games. Kupp will be the focal point for Los Angeles' offense against a Vikings defense that is giving up 380.6 yards per game this season, which ranks 30th in the NFL. Lock him in your NFL DFS lineups and look for a big return against Minnesota.

How to set NFL DFS lineups for Week 16

McClure is also targeting an undervalued player who is set to explode for huge numbers in Week 16. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here. 

So who is Mike McClure putting in his optimal NFL DFS lineups for Week 16? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with nearly $2 million in winnings, and find out.