Hot topics close

Assessing the relationship between gut microbiota and ...

Assessing the relationship between gut microbiota and
Background An increasing body of observational studies have indicated an association between gut microbiota and endometriosis. However, the causal relationship between them is not yet clear. In this study, we employed Mendelian randomization method to inv
  • Filby CE, Rombauts L, Montgomery GW, Giudice LC, Gargett CE. Cellular origins of endometriosis: towards Novel Diagnostics and therapeutics. Semin Reprod Med. 2020;38:201–15.

    Article  CAS  PubMed  Google Scholar 

  • Engemise S, Gordon C, Konje JC, Endometriosis. BMJ. 2010;340:c2168.

    Article  PubMed  Google Scholar 

  • La Rosa VL, Barra F, Chiofalo B, Platania A, Di Guardo F, Conway F, et al. An overview on the relationship between endometriosis and infertility: the impact on sexuality and psychological well-being. J Psychosom Obstet Gynaecol. 2020;41:93–7.

    Article  PubMed  Google Scholar 

  • Barandouzi ZA, Starkweather AR, Henderson WA, Gyamfi A, Cong XS. Altered composition of Gut Microbiota in Depression: a systematic review. Front Psychiatry. 2020;11:541.

    Article  PubMed  PubMed Central  Google Scholar 

  • Marques FZ, Jama HA, Tsyganov K, Gill PA, Rhys-Jones D, Muralitharan RR, et al. Guidelines for transparency on gut Microbiome studies in essential and experimental hypertension. Hypertension. 2019;74:1279–93.

    Article  CAS  PubMed  Google Scholar 

  • Woodall CA, McGeoch LJ, Hay AD, Hammond A. Respiratory tract infections and gut microbiome modifications: a systematic review. PLoS ONE. 2022;17:e0262057.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bauşic AIG, Creţoiu SM, Bauşic V, Matasariu DR, Stănculescu RV, Brătilă E. The role of gut dysbiosis in endometriosis’ diagnosis and treatment approaches - case report. Rom J Morphol Embryol. 2023;64:263–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Iavarone I, Greco PF, La Verde M, Morlando M, Torella M, de Franciscis P, et al. Correlations between Gut Microbial Composition, Pathophysiological and Surgical aspects in Endometriosis: a review of the literature. Med (Kaunas). 2023;59:347.

    Google Scholar 

  • Benagiano G, Brosens I, Lippi D. Endometriosis: ancient or modern disease? Indian J Med Res. 2015;141:236–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chiaffarino F, Cipriani S, Ricci E, Roncella E, Mauri PA, Parazzini F, et al. Endometriosis and inflammatory bowel disease: a systematic review of the literature. Eur J Obstet Gynecol Reprod Biol. 2020;252:246–51.

    Article  PubMed  Google Scholar 

  • Forbes JD, Chen CY, Knox NC, Marrie RA, El-Gabalawy H, de Kievit T, et al. A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist? Microbiome. 2018;6:221.

    Article  PubMed  PubMed Central  Google Scholar 

  • West CE, Renz H, Jenmalm MC, Kozyrskyj AL, Allen KJ, Vuillermin P, et al. The gut microbiota and inflammatory noncommunicable diseases: associations and potentials for gut microbiota therapies. J Allergy Clin Immunol. 2015;135:3–13.

    Article  PubMed  Google Scholar 

  • Hariton E, Locascio JJ. Randomised controlled trials - the gold standard for effectiveness research: study design: randomised controlled trials. BJOG. 2018;125:1716.

    Article  PubMed  PubMed Central  Google Scholar 

  • Carnegie R, Zheng J, Sallis HM, Jones HJ, Wade KH, Evans J, et al. Mendelian randomisation for nutritional psychiatry. Lancet Psychiatry. 2020;7:208–16.

    Article  PubMed  Google Scholar 

  • Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008;27:1133–63.

    Article  MathSciNet  PubMed  Google Scholar 

  • Kurilshikov A, Medina-Gomez C, Bacigalupe R, Radjabzadeh D, Wang J, Demirkan A, et al. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat Genet. 2021;53:156–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife. 2018;7:e34408.

    Article  PubMed  PubMed Central  Google Scholar 

  • Slatkin M. Linkage disequilibrium–understanding the evolutionary past and mapping the medical future. Nat Rev Genet. 2008;9:477–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhuang Z, Yu C, Guo Y, Bian Z, Yang L, Millwood IY, et al. Metabolic Signatures of Genetically Elevated Vitamin D among Chinese: observational and mendelian randomization study. J Clin Endocrinol Metab. 2021;106:e3249–60.

    Article  PubMed  Google Scholar 

  • Hartwig FP, Davies NM, Hemani G, Davey Smith G. Two-sample mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique. Int J Epidemiol. 2016;45:1717–26.

    Article  PubMed  Google Scholar 

  • Wu F, Huang Y, Hu J, Shao Z. Mendelian randomization study of inflammatory bowel disease and bone mineral density. BMC Med. 2020;18:312.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bowden J, Spiller W, Del Greco MF, Sheehan N, Thompson J, Minelli C, et al. Improving the visualization, interpretation and analysis of two-sample summary data mendelian randomization via the Radial plot and radial regression. Int J Epidemiol. 2018;47:2100.

    Article  PubMed  PubMed Central  Google Scholar 

  • Verbanck M, Chen CY, Neale B, Do R. Publisher correction: detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat Genet. 2018;50:1196.

    Article  CAS  PubMed  Google Scholar 

  • Carter AR, Sanderson E, Hammerton G, Richmond RC, Davey Smith G, Heron J, et al. Mendelian randomisation for mediation analysis: current methods and challenges for implementation. Eur J Epidemiol. 2021;36:465–78.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gronau QF, Wagenmakers EJ. Limitations of bayesian leave-one-out Cross-validation for Model Selection. Comput Brain Behav. 2019;2:1–11.

    Article  PubMed  Google Scholar 

  • Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362:2389–98.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ahn SH, Monsanto SP, Miller C, Singh SS, Thomas R, Tayade C. Pathophysiology and Immune Dysfunction in Endometriosis. Biomed Res Int. 2015;2015:795976.

    Article  PubMed  PubMed Central  Google Scholar 

  • Han SJ, O’Malley BW. The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis. Hum Reprod Update. 2014;20:467–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arpaia N, Rudensky AY. Microbial metabolites control gut inflammatory responses. Proc Natl Acad Sci U S A. 2014;111:2058–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Marsland BJ. Regulating inflammation with microbial metabolites. Nat Med. 2016;22:581–3.

    Article  CAS  PubMed  Google Scholar 

  • Chang PV, Hao L, Offermanns S, Medzhitov R. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2014;111:2247–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chadchan SB, Cheng M, Parnell LA, Yin Y, Schriefer A, Mysorekar IU, et al. Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota. Hum Reprod. 2019;34:1106–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shan J, Ni Z, Cheng W, Zhou L, Zhai D, Sun S, et al. Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3/4 endometriosis. Arch Gynecol Obstet. 2021;304:1363–73.

    Article  CAS  PubMed  Google Scholar 

  • Qi X, Yun C, Pang Y, Qiao J. The impact of the gut microbiota on the reproductive and metabolic endocrine system. Gut Microbes. 2021;13:1–21.

    Article  PubMed  Google Scholar 

  • Ervin SM, Li H, Lim L, Roberts LR, Liang X, Mani S, et al. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens. J Biol Chem. 2019;294:18586–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Le N, Cregger M, Brown V, Loret de Mola J, Bremer P, Nguyen L, et al. Association of microbial dynamics with urinary estrogens and estrogen metabolites in patients with endometriosis. PLoS ONE. 2021;16:e0261362.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • d’Afflitto M, Upadhyaya A, Green A, Peiris M. Association between sex hormone levels and gut microbiota composition and Diversity-A systematic review. J Clin Gastroenterol. 2022;56:384–92.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cong J, Zhou P, Zhang R. Intestinal microbiota-derived short chain fatty acids in host health and disease. Nutrients. 2022;14:1977.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mikhael S, Punjala-Patel A, Gavrilova-Jordan L. Hypothalamic-pituitary-ovarian Axis disorders Impacting Female Fertility. Biomedicines. 2019;7:5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Baj A, Moro E, Bistoletti M, Orlandi V, Crema F, Giaroni C. Glutamatergic signaling along the Microbiota-Gut-Brain Axis. Int J Mol Sci. 2019;20:1482.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Perrotta AR, Borrelli GM, Martins CO, Kallas EG, Sanabani SS, Griffith LG, et al. The vaginal microbiome as a Tool to predict rASRM Stage of Disease in Endometriosis: a pilot study. Reprod Sci. 2020;27:1064–73.

    Article  CAS  PubMed  Google Scholar 

  • Chen C, Song X, Wei W, Zhong H, Dai J, Lan Z, et al. The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nat Commun. 2017;8:875.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bendifallah S, Dabi Y, Suisse S, Delbos L, Spiers A, Poilblanc M, et al. Validation of a salivary miRNA signature of endometriosis-interim data. NEJM Evid. 2023;2:EVIDoa2200282.

    Article  PubMed  Google Scholar 

  • Meisel SF, Beeken RJ, van Jaarsveld CH, Wardle J. Genetic susceptibility testing and readiness to control weight: results from a randomized controlled trial. Obes (Silver Spring). 2015;23:305–12.

    Article  Google Scholar 

  • Agustí A, Melén E, DeMeo DL, Breyer-Kohansal R, Faner R. Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene-environment interactions across the lifespan. Lancet Respir Med. 2022;10:512–24.

    Article  PubMed  Google Scholar 

  • Similar news
    News Archive
    • MetLife
      MetLife
      FWD completes MetLife Hong Kong acquisition
      9 Jul 2024
      2
    • Nigeria vs Ghana
      Nigeria vs Ghana
      Nigeria vs Ghana: Prediction, kick-off time, TV, live stream, team ...
      22 Mar 2024
      4
    • Bournemouth fire
      Bournemouth fire
      Bournemouth beach fire started by kettle boiled to treat weever fish sting
      21 Jul 2020
      1
    • Reading FC
      Reading FC
      Schools & Grassroots returns... prizes on offer!
      24 Jan 2024
      24