England vs Ireland live score updates from the Six Nations clash
Ireland travel to Twickenham knowing only a win over England will keep their hopes of winning the 2022 Six Nations title alive.
With Grand-Slam chasing France winning in Cardiff on Friday night, there is no room for slip ups for either Ireland or England.
The bookies make Ireland the marginal favourites to record their first win at Twickenham since 2018.
Andy Farrell's side came up short in Paris before a farcical win over Italy last time out.
They have to deal with championship-ending injuries to Andrew Porter and Ronan Kelleher in the front row.
But England have their injury problems of their own, with the likes of Owen Farrell, Jonny May, Manu Tuilagi and Anthony Watson on the sidelines.
Check out our updates from the game (courtesy of the Irish Mirror ) - kick-off is at 4.45pm.