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The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities | Communications Biology

The frequency of pathogenic variation in the All of Us cohort reveals 
ancestrydriven disparities  Communications Biology
A comparison of the frequency of pathogenic mutations in 73 genes in the All of Us cohort highlights the differences in pathogenic variation attributed to ancestry.
  • Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

    Eric Venner, Divya Kalra, Yi-Ju Chen, Sara E. Kalla, Bo Yuan, Kimberly Walker, Qiaoyan Wang & Richard A. Gibbs

  • Department of Genome Sciences, University of Washington, Seattle, WA, USA

    Karynne Patterson, Marsha M. Wheeler, Joshua D. Smith, Sean McGee & Aparna Radhakrishnan

  • University of Arizona, R Ken Coit College of Pharmacy, Department of Pharmacy Practice and Science, Tucson, AZ, USA

    Jason H. Karnes

  • Vanderbilt University Medical Center, Department of Biomedical Informatics, Boston, MA, USA

    Jason H. Karnes

  • Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA

    Andrew Haddad

  • Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA

    Philip E. Empey

  • Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Lee Lichtenstein & Diana Toledo

  • Department of Medicine (Medical Genetics), University of Washington School of Medicine, Seattle, WA, USA

    Gail Jarvik

  • Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA

    Gail Jarvik

  • NIH All of Us Research Program, National Institutes of Health Office of the Director, Bethesda, MD, USA

    Anjene Musick

  • Henry Ford Health System, Detroit, MI, USA

    Brian Ahmedani, Christine D. Cole Johnson & Cathryn Peltz-Rauchman

  • University of Chicago Medical Center, Chicago, IL, USA

    Habib Ahsan

  • University of California, Irvine - Irvine, California, CA, USA

    Hoda Anton-Culver

  • Scripps Research Translational Institute - La Jolla, California, CA, USA

    Eric Topol, Katie Baca-Motes, Julia Moore-Vogel & Evan Muse

  • Vibrent Health, Fairfax, VA, USA

    Praduman Jain, Mark Begale, Neeta Jain, David Klein & Scott Sutherland

  • University of Alabama at Birmingham, Birmingham, AL, USA

    Bruce Korf & Beth Lewis

  • Columbia University - New York City, New York, NY, USA

    Ali G. Gharavi & George Hripcsak

  • University of Texas Health Science Center at Houston, Houston, TX, USA

    Eric Boerwinkle & David McPherson

  • Marshfield Clinic Research Institute, Marshfield, WI, USA

    Scott Joseph Hebbring & Sanjay Skukla

  • University of Wisconsin at Madison, Madison, WI, USA

    Elizabeth Burnside & Dorothy Farrar-Edwards

  • Community Health Center, Inc., Middletown, CT, USA

    Amy Taylor & Katrina Yamazaki

  • Sun River Health - Beacon, New York, NY, USA

    Liliana Lombardi Desa & Kathleen Keogh

  • Mayo Clinic and Foundation, Rochester, MN, USA

    Steve Thibodeau & Mine Cicek

  • Cooperative Health, South Carolina, SC, USA

    Eric Schlueter & Beverly Wilson Holmes

  • University of Illinois at Chicago, Evanston, IL, USA

    Martha Daviglus, Maria Argos & Brisa Aschebook-Kilfoy

  • Vanderbilt University Medical Center, Nashville, TN, USA

    Paul Harris, Consuelo Wilkins,  Dan Roden & Melissa Basford

  • Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Kim Doheny

  • University of Washington, Seattle, Washington, WA, USA

    Evan Eichler & Gail Jarvik

  • FiftyForward, Nashville, TN, USA

    Gretchen Funk

  • Broad Institute - Boston Massachusetts, Boston, USA

    Anthony Philippakis, Heidi Rehm, Stacey Gabriel & Niall Lennon

  • Baylor College of Medicine, Houston, TX, USA

    Richard Gibbs, Brendan Lee & Laura Rosales

  • National Alliance for Hispanic Health, Washington, DC, USA

    Edgar M. Gil Rico & Adolph Falcon

  • Verily Life Sciences - South San Francisco, California, CA, USA

    David Glazer

  • MITRE Corporation, McLean, VA, USA

    Jessica Burke

  • Northwestern University, Evanston, IL, USA

    Philip Greenland & Joyce Ho

  • University of Florida, Gainesville, FL, USA

    Elizabeth Shenkman, William R. Hogan & Eileen Handberg

  • Morehouse School of Medicine, Atlanta, GA, USA

    Priscilla Igho-Pemu & Robert Meller

  • Partners Health Care - Boston, Massachusetts, MA, USA

    Elizabeth W. Karlson, Jordan Smoller & Shawn N. Murphy

  • Cornell University, Weill Medical College - New York City, New York, NY, USA

    Margaret Elizabeth Ross & Rainu Kaushal

  • Cherokee Health Systems, Knoxville, TN, USA

    Eboni Winford, Gail Reilly, Kyla Taylor & Daniel Hernandez Tinoco

  • CareEvolution, Inc, Ann Arbor, MI, USA

    Vik Kheterpal

  • University of Arizona, Tucson, Tucson, AZ, USA

    Francisco A. Moreno

  • Delta Research and Educational Foundation, Washington, DC, USA

    Cheryl Thomas

  • Stanford University - Stanford, California, CA, USA

    Mitchell Lunn & Juno Obedin-Maliver

  • University of Pittsburgh, Pittsburgh, PA, USA

    Oscar Marroquin, Shyam Visweswaran & Steven Reis

  • Wondros - Los Angeles, California, CA, USA

    Patrick McGovern

  • San Ysidro Health Center - San Ysidro, California, CA, USA

    Gregory Talavera & Linda Salgin

  • Boston Medical Center - Boston, Massachusetts, MA, USA

    George T. O’Connor

  • University of California, San Diego – San Diego, California, CA, USA

    Lucila Ohno-Machado, Amy Sitapati & Amaryllis Silva Boschetti

  • Asian Health Coalition, Chicago, IL, USA

    Fornessa Randal

  • Banner Health, Phoenix, AZ, USA

    Andreas A. Theodorou & Eric Reiman

  • Montage Marketing Group, Rockville, MD, USA

    Mercedita Roxas-Murray

  • University of Utah, Salt Lake City, Utah, USA

    Louisa Stark

  • HCM Strategists, Austin, TX, USA

    Ronnie Tepp

  • Color Genomics, Inc. – Burlingame, California, CA, USA

    Alicia Zhou & Scott Topper

  • NYC Health + Hospitals - New York City, New York, NY, USA

    Rhonda Trousdale

  • VA AoU Coordinating Center - Palo Alto, California, CA, USA

    Phil Tsao

  • Brigham and Women’s Hospital – Boston, Massachusetts, MA, USA

    Scott T. Weiss & Cheryl Clark

  • Medical College of Wisconsin, Milwaukee, WI, USA

    Jeffrey Whittle & Zeno Frano

  • University of Miami School of Medicine, Miami, FL, USA

    Stephan Zuchner, Olveen Carrasquillo, Rosario Isasi & Jacob McCauley

  • Research Triangle Institute - Research Triangle Park, Raleigh, NC, USA

    Megan Lewis & Jen Uhrig

  • Waianae Coast CHC, Waianae, HI, USA

    May Okihiro & Emily Makahi

  • National Library of Medicine (NLM), Bethesda, MD, USA

    Laura Bartlett

  • American Association of Health and Disability, Sedona, AZ, USA

    Roberta Carlin, Karl Cooper & Charles Drum

  • Hunter College - New York City, New York, NY, USA

    Elizabeth Cohn & Frida Kleiman

  • University of Puerto Rico Comprehensive Cancer Center, San Juan, WA, USA

    Vivian Colon-Lopez & Jose Melo

  • CTSA Community Engagement Programs, Gainesville, FL, USA

    Linda Cottler & Milton Eder

  • University of South Alabama, Mobile, AL, USA

    Errol Crook

  • TPC: Blood Assurance - Signal Mountain, Tennessee, TN, USA

    Elizabeth Culler

  • San Diego Blood Bank – San Diego, California, CA, USA

    Mark Edmunds

  • TPC: Denver Health - Denver, Colorado, CO, USA

    Rachel Everhart

  • TPC: Active Minds -, Washington, DC, USA

    Becky Fein & Laura Horne

  • University of Mississippi Medical Center, Jackson, MS, USA

    Michael Garrett & Babbette Lamarca

  • TPC: DLH Corp, Atlanta, GA, USA

    Sandra Halverson

  • Mass General Hospital - Boston, Massachusetts, MA, USA

    Jessica Isom, Cynthia So-Armah & Paul Nemeskal

  • Tactis -, Washington, DC, USA

    Jessica Jarmin

  • TPC: Mary’s Center -, Washington, DC, USA

    Megan Jula

  • TPC: Owaves -, Washington, DC, USA

    Royan Kamyar

  • Harvard Medical School - Boston, Massachusetts, MA, USA

    Isaac Kohane

  • National Baptist Convention, Nashville, TN, USA

    Dessie Levy & Michael Minor

  • Gundersen Health System, La Crosse, WI, USA

    Todd Mahr

  • South Texas Blood and Tissue Center, San Antonio, TX, USA

    Vivienne Marshall

  • University of North Carolina at Chapel Hill - Chapel Hill, Chapel Hill, NC, USA

    Elizabeth Mayer-Davis

  • Sensis - Glendale, California, CA, USA

    Jeffrey McKinney & Jamie Walz

  • TPC: Bloodworks Northwest – Seattle, Washington, WA, USA

    David Ming-Hung Lin

  • TPC: Fitbit - San Francisco, California, CA, USA

    Kapil Parakh

  • COSSMA, Aibonito, PR, Puerto Rico

    Linda Perez Laras & Nelida Rivera

  • Patients Like Me, Houston, TX, USA

    Subhara Raveendran

  • Quest Diagnostics Incorporated – Secaucus, Secaucus, NJ, USA

    Jody Reilly & Yuri Fresko

  • Emory University, Atlanta, GA, USA

    Tracie Rosser, Suchitra Chandrasekaran, Robert Kelley, Matt Pagel & Miriam Vos

  • VA AoU Coordinating Center - Boston, Massachusetts, MA, USA

    Sherilyn Sawyer & Jason Vassy

  • Cascade Regional Blood Services - Tacoma, Washington, WA, USA

    William Simonson

  • ExamOne, Mission, KS, USA

    Gene Stegeman

  • Sage Bionetworks – Seattle, Washington, WA, USA

    Christin Suver

  • Walgreen Co., Deerfield, IL, USA

    Michael Taitel

  • WebMD Health Corp – New York City, New York, NY, USA

    Preston Watkins

  • Blue Cross Blue Shield, Chicago, IL, USA

    Blaker Wilkerson

  • Saint Louis University, Saint Louis, MO, USA

    Matthew Breeden, Kim Enard, Richard Grucza, Ted Malmstrom & Jeffrey Scherrer

  • Mount Sinai Health System - New York City, New York, NY, USA

    Monica Kraft

  • LifeSouth, Gainesville, FL, USA

    Christopher Lough

  • SunCoast Blood Center, Bradenton, FL, USA

    Debra Smith

  • University Southern California - Los Angeles, California, CA, USA

    Bryce Turner

  • Conceived and designed the analysis: E.V., A.M., R.G., G.J., P.E. Collected the data: E.V., D.K., K.P., M.W., Y.C., L.L. Performed the analysis: E.V., K.P., D.K., M.W., Y.C. Wrote the paper: E.V., K.P., D.K., M.W., Y.C., S.K., B.Y., J.K., K.W., J.S., S.M., A.R., A.H., P.E., Q.W., L.L., D.T., G.J., A.M., R.G.

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