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There was no mention of O.J. Simpson on Kim Kardashian’s Instagram page on Thursday.

Early that morning, she posted a video promoting a hoodie and bike shorts from Skims, the clothing company she co-founded. Later in the day, after the Simpson family announced that Mr. Simpson had died of cancer at age 76, Ms. Kardashian was silent on social media.

Over the decades, her family had distanced itself from the man who played a significant role in propping up the Kardashian name.

Kim’s father, Robert Kardashian, met Mr. Simpson through their ties to the University of Southern California in Los Angeles. Mr. Kardashian earned a business degree there in 1966, and Mr. Simpson was a star running back for the school in 1967 and 1968.

The two became close in the 1970s, when Mr. Simpson was a standout in the National Football League and Mr. Kardashian was a rising lawyer and entrepreneur in Los Angeles. His businesses included entertainment properties and a frozen yogurt company.

When Mr. Kardashian married the former Kris Houghton (now Kris Jenner) in 1978, Mr. Simpson served as his best man. The couple had four children — Kim, Kourtney, Khloe and Robert Jr. The marriage ended in divorce in 1991. That same year, Ms. Jenner married the former Olympian who now goes by Caitlyn Jenner.

Mr. Simpson met Nicole Brown in 1977, when he was still married to his first wife. During a separation from his wife, he lived for a time with Mr. Kardashian at his home, Mr. Simpson wrote in his 2007 book, “If I Did It.”