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Good morning. Here in Chicago, residents are reeling over the removal of the famed rat hole, a rat-shaped indentation on a piece of sidewalk that drew crowds, fans, and even a proposal and a marriage.

The need-to-know this morning

A hospital takes a gene therapy’s approval into its own hands

What happens if, as an academic, you develop a promising gene therapy, but no company is willing to take it to market? Well, one option is — you do it yourself.

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